End-to-end autonomous driving, as a relatively new paradigm (compared to the modular design) yet with great potential, has already attracted attention from both academia and industry. This workshop serves a brand-new perspective to discuss broad areas of end-to-end framework design for autonomous driving on a system-level consideration. Central to the program is a series of invited talks and four new challenges in the self-driving domain. Each challenge combines new perspectives of multiple components in perception and planning compared to conventional pipelines.