Open-world interpretation aims to accurately localize and recognize all objects within images by vision-language models (VLMs). While substantial progress has been made in this task for natural images, the advancements for remote sensing (RS) images still remain limited, primarily due to these two challenges. 1) Existing RS semantic categories are limited, particularly for pixel-level interpretation datasets. 2) Distinguishing among diverse RS spatial regions solely by language space is challenging due to the dense and intricate spatial distribution in open-world RS imagery. To address the first issue, we develop a fine-grained RS interpretation dataset, Sky-SA, which contains 183,375 high-quality local image-text pairs with full-pixel manual annotations, covering 1,763 category labels, exhibiting richer semantics and higher density than previous datasets. Afterwards, to solve the second issue, we introduce the vision-centric principle for vision-language modeling. Specifically, in the pre-training stage, the visual self-supervised paradigm is incorporated into image-text alignment, reducing the degradation of general visual representation capabilities of existing paradigms. Then, we construct a visual-relevance knowledge graph across open-category texts and further develop a novel vision-centric image-text contrastive loss for fine-tuning with text prompts. This new model, denoted as SkySense-O, demonstrates impressive zero-shot capabilities on a thorough evaluation encompassing 14 datasets over 4 tasks, from recognizing to reasoning and classification to localization. Specifically, it outperforms the latest models such as SegEarth-OV, GeoRSCLIP, and VHM by a large margin, i.e., 11.95\%, 8.04\% and 3.55\% on average respectively. We will release the dataset and model to facilitate future research.