Out-of-distribution (OOD) detection is crucial for ensuring the robustness of machine learning models by identifying samples that deviate from the training distribution. While traditional OOD detection has predominantly focused on single-modality inputs, such as images, recent advancements in multimodal models have shown the potential of utilizing multiple modalities (e.g., video, optical flow, audio) to improve detection performance. However, existing approaches often neglect intra-class variability within in-distribution (ID) data, assuming that samples of the same class are perfectly cohesive and consistent. This assumption can lead to performance degradation, especially when prediction discrepancies are indiscriminately amplified across all samples. To address this issue, we propose Dynamic Prototype Updating (DPU), a novel plug-and-play framework for multimodal OOD detection that accounts for intra-class variations. Our method dynamically updates class center representations for each class by measuring the variance of similar samples within each batch, enabling tailored adjustments. This approach allows us to intensify prediction discrepancies based on the updated class centers, thereby enhancing the model’s robustness and generalization across different modalities. Extensive experiments on two tasks, five datasets, and nine base OOD algorithms demonstrate that DPU significantly improves OOD detection performances, setting a new state-of-the-art in multimodal OOD detection, including improvements up to 80% in Far-OOD detection.To improve accessibility and reproducibility, our code is released anonymously at https://anonymous.4open.science/r/CVPR-9177.