Instruction tuning enhances large vision-language models (LVLMs) but increases their vulnerability to backdoor attacks due to their open design. Unlike prior studies in static settings, this paper explores backdoor attacks in LVLM instruction tuning across mismatched training and testing domains. We introduce a new evaluation dimension, backdoor domain generalization, to assess attack robustness under visual and text domain shifts. Our findings reveal two insights: (1) backdoor generalizability improves when distinctive trigger patterns are independent of specific data domains or model architectures, and (2) triggers placed in preference over clean semantic regions significantly enhance attack generalization. Based on these insights, we propose a multimodal attribution backdoor attack (MABA) that injects domain-agnostic triggers into critical areas using attributional interpretation. Experiments with OpenFlamingo, Blip-2, and Otter show that MABA significantly boosts the attack success rate of generalization by 36.4\%, achieving a 97\% success rate at a 0.2\% poisoning rate. This study reveals limitations in current evaluations and highlights how enhanced backdoor generalizability poses a security threat to LVLMs, even without test data access.