This paper introduces Comprehensive Relighting, the first all-in-one approach that can both control and harmonize the lighting from an image or video of humans with arbitrary body parts from any scene. Building such a generalizable model is extremely challenging due to the lack of dataset, restricting existing image-based relighting models to a specific scenario (e.g, face or static human). To address this challenge, we repurpose a pre-trained diffusion model as a general image prior and jointly model the human relighting and background harmonization in the coarse-to-fine framework. further enhance the temporal coherence of the relighting, we introduce an unsupervised temporal lighting model that learns the lighting cycle consistency from many real-world videos without any ground truth.In inference time, our motion module is combined with the diffusion models through the spatio-temporal feature blending algorithms without extra training; and we apply a new guided refinement as a post-processing to preserve the high-frequency details from the input image. In the experiments, Comprehensive Relighting shows a strong generalizability and lighting temporal coherence, outperforming existing image-based human relighting and harmonization methods.