This paper pays attention to Weakly Supervised Affordance Grounding (WSAG) task that aims to train model to identify affordance regions using human-object interaction images and egocentric images without the need for costly pixel-level annotations. Most existing methods usually consider the affordance regions to be isolated and directly employ class activation maps to conduct localization, ignoring the relation with other object components and weakening the performance. For example, a cup’s handle is combined with its body to achieve the pouring ability. Obviously, capturing the region relations is beneficial for improving the localization accuracy of affordance regions. To this end, we first explore exploiting hypergraph to discover these relations and propose a Reasoning Mamba (R-Mamba) framework.We first extract feature embeddings from exocentric and egocentric images to construct the hypergraphs consisting of multiple vertices and hyperedges, which capture the in-context local region relationships between different visual components. Subsequently, we design a Hypergraph-guided State Space (HSS) block to reorganize these local relationships from the global perspective. By this mechanism, the model could leverage the captured relationships to improve the localization accuracy of affordance regions. Extensive experiments and visualization analyses demonstrate the superiorities of our method.