LUMINA: A Multi-Vendor Mammography Benchmark with Energy Harmonization Protocol

Publicly available full-field digital mammography (FFDM) datasets remain limited in size, clinical labels, and vendor diversity, which hinders the training of robust models. We present \textbf{LUMINA}, a curated, multi-vendor FFDM dataset that explicitly encodes acquisition energy and vendor metadata to expose clinically relevant appearance shifts that current benchmarks overlook. This innovative resource comprises 1824 images from 468 patients (960 benign, 864 malignant) with pathology-confirmed outcomes, BI-RADS assessments, and breast-density annotations. LUMINA spans six acquisition systems and both high- and low-energy styles, exposing vendor- and energy-driven appearance shifts. To reduce cross‑vendor/energy drift while preserving lesion morphology, we introduce a \textit{foreground‑only}, pixel‑space alignment (“energy harmonization”) that aligns each image to a low‑energy reference style, leaving the zero‑valued background unchanged. By benchmarking modern CNN and transformer baselines on three clinically meaningful tasks—diagnosis (benign vs. malignant), BI‑RADS risk grouping, and density—we unify single‑vs‑two‑view evaluation and show that two‑view models consistently outperform single‑view; in our benchmark, EfficientNet‑B0 ($512^2$) attains AUC 93.61\% for diagnosis, and Swin‑T yields the best macro‑AUC 89.10\% for density. Harmonization improves AUC/ACC across backbones and yields more focal Grad‑CAM localization around suspicious regions. Being a richly annotated resource, LUMINA thus provides (a) a vendor‑diverse, energy‑labeled benchmark and (b) a model‑agnostic harmonization protocol that together catalyze reliable, deployable mammography AI.