Driven by the advancements in generative AI, large machine learning models have revolutionized domains such as image processing, audio synthesis, and speech recognition. While server-based deployments remain the locus of peak performance, the imperative for on-device inference, necessitated by privacy and efficiency considerations, persists. Recognizing GPUs as the on-device ML accelerator with the widest reach, we present ML Drift–an optimized framework that extends the capabilities of state-of-the-art GPU-accelerated inference engines. ML Drift enables on-device execution of generative AI workloads which contain 10 to 100× more parameters than existing on-device generative AI models. ML Drift addresses intricate engineering challenges associated with cross-GPU API development, and ensures broad compatibility across mobile and desktop/laptop platforms, thereby facilitating the deployment of significantly more complex models on resource-constrained devices. Our GPU accelerated ML/AI inference engine achieves an order-of-magnitude performance improvement relative to existing open-source GPU inference engines.