Abstract: Graphical User Interface (GUI) agents show amazing abilities in assisting human-computer interaction, automating human user's navigation on digital devices. An ideal GUI agent is expected to achieve high accuracy, low latency, and compatibility for different GUI platforms. Recent vision-based approaches have shown promise by leveraging advanced Vision Language Models (VLMs). While they generally meet the requirements of compatibility and low latency, these vision-based GUI agents tend to have low accuracy due to their limitations in element grounding. To address this issue, we propose $\textbf{SpiritSight}$, a vision-based, end-to-end GUI agent that excels in GUI navigation tasks across various GUI platforms. First, we create a multi-level, large-scale, high-quality GUI dataset called $\textbf{GUI-Lasagne}$ using scalable methods, empowering SpiritSight with robust GUI understanding and grounding capabilities. Second, we introduce the $\textbf{Universal Block Parsing (UBP)}$ method to resolve the ambiguity problem in dynamic high-resolution of visual inputs, further enhancing SpiritSight's ability to ground GUI objects. Through these efforts, SpiritSight agent outperforms other advanced methods on diverse GUI benchmarks, demonstrating its superior capability and compatibility in GUI navigation tasks. The models and code will be made available upon publications.