We introduce SemanticDraw, a new paradigm of interactive content creation where high-quality images are generated in near real-time from given multiple hand-drawn regions, each encoding prescribed semantic meaning. In order to maximize the productivity of content creators and to fully realize their artistic imagination, it requires both quick interactive interfaces and fine-grained regional controls in their tools. Despite astonishing generation quality from recent diffusion models, we find that existing approaches for regional controllability are very slow (52 seconds for 512 x 512 image) while not compatible with acceleration methods such as LCM, blocking their huge potential in interactive content creation. From this observation, we build our solution for interactive content creation in two steps: (1) we establish compatibility between region-based controls and acceleration techniques for diffusion models, maintaining high fidelity of multi-prompt image generation with x 10 reduced number of inference steps, (2) we increase the generation throughput with our new multi-prompt stream batch pipeline, enabling low-latency generation from multiple, region-based text prompts on a single RTX 2080 Ti GPU. Our proposed framework is generalizable to any existing diffusion models and acceleration schedulers, allowing sub-second (0.64 seconds) image content creation application upon well-established image diffusion models. The demo application can be found in Supplementary Material.